Retinoid targets for apoptosis induction
نویسندگان
چکیده
منابع مشابه
Evidence supporting a role for mitochondrial respiration in apoptosis induction by the synthetic retinoid CD437.
Retinoids have been shown to modulate cell proliferation, differentiation, and apoptosis. It is thought that these effects mediate the chemopreventive and therapeutic effects of retinoids. Recently, some synthetic retinoids, including 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437), have been found to induce apoptosis even in tumor cell lines that are resistant to all-...
متن کاملPromyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression.
BACKGROUND AND OBJECTIVES Retinoids are involved in cell differentiation, morphogenesis, proliferation and antineoplasic processes. Thus, the retonoic acid receptor (RARalpha) agonist, AM80, regulates tissue factor (TF), thrombomodulin (TM) expression and granulocytic differentiation in promyelocytic cells, while the RARgamma-selective retinoid, CD437, inhibits in vitro cell proliferation and i...
متن کاملApoptosis Induction by a Novel Retinoid-Related Molecule Requires Nuclear Factor-KB Activation
Nuclear factor-KB (NF-KB) activation has been shown to be both antiapoptotic and proapoptotic depending on the stimulus and the specific cell type involved. NF-KB activation has also been shown to be essential for apoptosis induction by a number of agents. The novel retinoid-related molecule 4-[3Cl-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid (3Cl-AHPC) activates NF-KB with subsequent a...
متن کاملInduction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.
Acute myelogenous leukemia (AML) is a heterogeneous disease consisting of a variety of different leukemic subtypes. While acute promyelocytic leukemia displays marked sensitivity to the differentiating effects of trans-retinoic acid (tRA), other subtypes of AML display resistance. We now describe a novel compound (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC/MM002) th...
متن کاملA retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis.
Some success in overcoming retinoic acid (RA)-resistance has been reported for acute promyelocytic leukemia in cell lines and the clinic by combining histone deacetylase inhibitors, like sodium butyrate (NaB), with RA. This epigenetic therapy counteracts the effects of nuclear corepressors, causing a DNA conformation that facilitates RA-induced gene transcription and cell differentiation. In an...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2003
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207109